[New Practice of Governing the Country-Guangdong] Vigorously promote "Internet+Government Services" and start the first shot of transforming government functions

  One year after the standardization of administrative examination and approval was fully promoted to the whole province, the provincial government will hold a video conference today to promote the reform of "Internet+government services" in the whole province. According to the information disclosed by the provincial editorial office, as the first move in the reform of "Internet+government services", Guangdong’s standardization of administrative examination and approval has achieved initial results, and will strive to complete the compilation, filing review and departmental confirmation of provincial administrative examination and approval standards in the first half of this year, and basically complete the compilation of provincial administrative licensing and public service standards before the end of the year.

  The central government attaches great importance to accelerating the transformation of government functions. At the Third Plenary Session of the 18th CPC Central Committee, it was proposed that we must effectively transform government functions, deepen administrative system reform, innovate administrative management methods, enhance government credibility and execution, and build a government ruled by law and a service-oriented government. At this year’s National People’s Congress, The Politburo Standing Committee (PSC) and Li Keqiang, Premier of the State Council of the People’s Republic of China of the Communist Party of China emphasized in their government work reports that "Internet+government services" should be vigorously promoted, so that residents and enterprises can run less errands, handle affairs well and avoid congestion.

  In recent years, Guangdong has vigorously promoted the standardization of administrative examination and approval. Hu Chunhua, secretary of the provincial party committee, attached great importance to it. Zhu Xiaodan, the governor, personally deployed the work at several meetings. Xu Shaohua, member of the Standing Committee of the provincial party committee and executive vice governor, personally implemented the work, and the leaders in charge of the province also gave strong support.

  It is understood that at present, the standards for administrative licensing matters of provincial departments have been successfully completed, and the standard templates for administrative licensing and public service matters at Foshan and Nanhai have also been completed, and the online and offline integration applications of standards have been steadily advanced.

  Reengineering approval process

  Create a transparent "cage" for the standardized operation of administrative examination and approval power

  "All the working conditions and application materials that are not based on laws, regulations and rules shall be cut off; All certificates that are not necessary or repeatedly required to be submitted shall be cancelled; All vague clauses, bottom clauses, additional clauses, etc. involved in the work process should be eliminated. " The relevant person in charge of the provincial editorial office said that promoting the standardization of administrative examination and approval and compiling the standards of administrative examination and approval items are by no means "new bottled old wine" and "changing the soup without changing the medicine", but to promote the reengineering of the examination and approval process, unify the administrative examination and approval standards and standardize the examination and approval behavior.

  The person in charge said that this reform has three remarkable characteristics. The first is to standardize and clarify the examination and approval elements. The second is to simplify and optimize the approval process. Greatly simplify and optimize the general approval process, greatly reduce the red tape of approval links, materials, time limit, licenses, intermediary services, etc., integrate and reduce, standardize and optimize the cross-level and inter-departmental approval procedures, and truly lower the threshold for handling affairs. The third is to refine and quantify the discretionary benchmark. It is required to strictly control the examination and approval conditions, refine the examination standards, clarify the procedures, contents, requirements and methods of the examination, quantify the criteria of approval, rectification, failure, etc., and list the rectification and failure in detail according to the requirement of "denial must be based". If there are no detailed standards and procedures for laws and regulations, the department is required to formulate relevant documents to be clearly regulated.

  Guangdong regards the preparation of standards for each administrative examination and approval item as the core content of the standardization of administrative examination and approval, and urges all relevant departments at the provincial level to prepare work guides and business manuals for each administrative examination and approval item and its sub-items in accordance with the Code for the Preparation of Business Manuals for Administrative Examination and Approval Items and the Code for the Preparation of Work Guides for Administrative Examination and Approval Items. At present, the standards of 1173 administrative licensing items (including sub-items) in 45 provincial departments have all been compiled and passed the compliance filing review. Among them, there are 160 items in provinces, cities and counties, 192 items in provinces and cities, 12 items in provinces and counties, and 809 items independently exercised by provinces. 1930 standard templates for administrative licensing and public service matters in 58 departments at Foshan and Nanhai levels have also been compiled.

  It is understood that each administrative examination and approval standard includes 13 examination and approval elements, including acceptance scope, handling basis, implementing agency, examination and approval conditions, application materials, examination and approval time limit, examination and approval documents, examination and approval fees, examination and approval personnel, examination and approval services and forms and documents. It covers 8 general approval processes, including appointment, application, acceptance, review, decision, certificate making and delivery, decision disclosure, supervision and inspection, and 11 other approval processes, including change, continuation, correction, cancellation, transfer, revocation, withdrawal, suspension and termination; At the same time, it also refines the post responsibilities, examination and approval authority, examination content, examination methods and other discretionary standards in each link.

  In order to facilitate the departments to understand and write the standards for entering administrative examination and approval items, the provincial editorial office decomposed the specific requirements for standardization of administrative examination and approval into 315 information fields, which were embedded in the standard entry module of administrative examination and approval items, so as to realize the proceduralization and informatization of the standard requirements. After the department enters the standards of administrative examination and approval items into the module as required, it automatically presents them as a service guide for administrative counterparts, and automatically generates a business manual for examination and approval personnel internally, which makes detailed and clear provisions on the whole process of administrative examination and approval implementation, creating a transparent "cage" for the standardized operation of administrative examination and approval power.

  The relevant person in charge of the provincial editorial office said that since the standardization of administrative examination and approval has been fully implemented, all relevant units directly under the provincial government and Foshan City and Nanhai District, which are pilot cities and counties, have attached great importance to it, and the main leaders of various localities and departments have personally asked questions, and the leaders in charge have grasped it to the end. After more than a year of joint efforts, the standards for administrative licensing matters of various departments directly under the provincial government have been successfully completed, and the templates for administrative licensing and public service matters at Foshan City and Nanhai District have also been compiled, and the online and offline integration applications of standards have been steadily advanced.

  The rules of handling affairs are more "transparent"

  Realized the real power of the department in the sun.

  "Through the implementation of standardization of administrative examination and approval, all kinds of hidden powers of various localities and departments have been comprehensively and without dead ends ‘ Big bottom ’ Every detail of the operation of power has been standardized and clarified one by one. " The relevant person in charge of the provincial editorial office said that the standardization of administrative examination and approval promoted by Guangdong since 2013 has been welcomed and supported by the vast number of enterprises and the people, and has also been affirmed by the central government and recognized by brother provinces and cities, and achieved initial results.

  He said that administrative power should be standardized and operated transparently. Standardization of administrative examination and approval standardizes and clarifies every detail of power operation one by one, clearly and clearly tells the masses where a power comes from, who to find, how to do it, how long it will take, how to complain, etc., and exposes the power of the department to the sun, so that the masses can do things according to the map, and the examination and approval personnel also fully follow the administrative examination and approval standards for examination and approval.

  Standardization of administrative examination and approval is an important foundation for the construction of e-government. By embedding administrative examination and approval standards into the examination and approval system of online service hall, Guangdong implements automation and information control over the whole process of administrative examination and approval, achieving standardized examination and approval, leaving traces on nodes, plastic process, correctable mistakes and traceable responsibilities, providing important business support for the whole process of online service, and gradually realizing online application, online acceptance, online approval and online consultation. It is understood that in 2015, there were 95,009 administrative examination and approval and public service items from all levels and departments in the provincial online service hall, and a total of 49.87 million transactions were handled throughout the year, with an online whole-process handling rate of 75.7%, an online handling rate of 77.6% and an online settlement rate of 72.2%, and the standardization of administrative examination and approval and service items across levels, departments and regions was gradually realized.

  In addition, through the implementation of standardization of administrative examination and approval, the discretionary space is greatly reduced, and the standards, processes and results of administrative examination and approval items are made public on the Internet, so as to minimize the influence of subjective factors in the examination and approval process, and strive for the masses to do things without looking for specific people, but to provide relevant materials directly according to the requirements of the service guide and complete the prescribed procedures, so as not to be different from place to place and from time to time, and gradually realize the same examination and approval items under the same conditions, and improve the transparency and fairness of examination and approval and services.

Building a new development pattern and taking a new step —— Interpreting the main economic data of 2021 by the heads of relevant departments of the National Bureau of Statistics

  In 2021, in the face of multiple tests such as the complicated and severe international environment and the spread of domestic epidemics, all localities and departments adhered to the general tone of striving for progress while maintaining stability, strengthened the cross-cycle adjustment of macro policies, and the national economy continued to recover and develop; Grain output reached a new high, and animal husbandry production grew steadily; Industrial production continued to develop, and high-tech manufacturing and equipment manufacturing industries grew rapidly; The energy supply has achieved remarkable results and the energy structure has been continuously optimized; The modern service industry is growing well.

  Sustained and stable recovery of the national economy

  Zhao Tonglu, Director of National Economic Accounting Department of National Bureau of Statistics

  In 2021, all localities and departments conscientiously implemented the decision-making arrangements of the CPC Central Committee and the State Council, scientifically coordinated epidemic prevention and control and economic and social development, China’s national economy sustained and stable recovery, high-quality development achieved new results, and the "14 th Five-Year Plan" achieved a good start.

  First, the economy showed a steady recovery trend.

  In 2021, China’s gross domestic product (hereinafter referred to as GDP) was 114,367 billion yuan, an increase of 8.1% over the previous year at constant prices, and the expected economic development target of more than 6% for the whole year was achieved, with an average growth rate of 5.1% for two years. Among them, the added value of the primary industry was 8,308.6 billion yuan, an increase of 7.1%, driving economic growth by 0.5 percentage points; The added value of the secondary industry was 45,090.4 billion yuan, an increase of 8.2%, driving economic growth by 3.1 percentage points; The added value of the tertiary industry was 60,968 billion yuan, an increase of 8.2%, driving economic growth by 4.5 percentage points. The added value of the three industries accounted for 7.3%, 39.4% and 53.3% of GDP respectively.

  Second, agriculture grew rapidly and the industrial service industry continued to recover.

  In 2021, the grain output reached a new high, and animal husbandry production grew steadily. The added value of agriculture, forestry, animal husbandry and fishery increased by 7.1% over the previous year, driving economic growth by 0.6 percentage points, of which the added value of agriculture, forestry, animal husbandry and fishery increased by 3.8 percentage points, with a contribution rate of 53.9%. Industrial production continued to recover, and the industrial added value increased by 9.6% over the previous year, driving economic growth by 3.0 percentage points. Among them, the added value of manufacturing industry increased by 9.8% over the previous year, accounting for 27.4% of GDP, up by 1.1 percentage points over the previous year. The added value of wholesale and retail, transportation, warehousing and postal services, accommodation and catering industry increased by 11.3%, 12.1% and 14.5% respectively over the previous year, which led to the recovery growth of service industry.

  Third, consumption plays an important role in economic recovery, and the role of external demand has increased.

  Consumer demand continued to be released, supporting the stable recovery of the national economy. Expanding domestic demand promotes the sustained development of consumption policy, and the contribution of consumption to economic growth has steadily increased, which has become the main driving force for the stable recovery of the national economy. In 2021, the contribution rate of final consumption expenditure to economic growth was 65.4%, driving GDP growth by 5.3 percentage points.

  Investment slowed down and stabilized, and development toughness increased. Major projects in the "14th Five-Year Plan" have been started one after another, and the infrastructure construction of "two new and one heavy" has been steadily advanced. In 2021, the contribution rate of total capital formation to economic growth was 13.7%, which boosted GDP growth by 1.1 percentage points.

  The growth of net exports is good, which promotes economic growth. In 2021, the contribution rate of net exports of goods and services to economic growth was 20.9%, driving GDP growth by 1.7 percentage points.

  Four, the key areas of rapid growth, structural optimization and upgrading.

  With the in-depth implementation of the supply-side structural reform and innovation-driven development strategy, in 2021, the investment in high-tech manufacturing industry increased by 22.2% over the previous year, which was 17.3 percentage points higher than the national fixed asset investment growth rate. The competitiveness of the manufacturing industry has been further improved. The added value of high-tech manufacturing industries above designated size increased by 18.2% over the previous year, which was significantly higher than the growth rate of all industries above designated size. The consumption structure of residents has been further improved, and the per capita consumption expenditure of residents nationwide has increased by 13.6% over the previous year. Per capita expenditure on education, culture and entertainment and per capita expenditure on health care increased by 27.9% and 14.8% respectively over the previous year.

  Agricultural production is generally stable and progressing.

  Wang Minghua, Deputy Director of Rural Social and Economic Investigation Department of National Bureau of Statistics.

  In 2021, all localities and departments will conscientiously implement the major decision-making arrangements of the CPC Central Committee and the State Council on agricultural development, and pay close attention to grain production. The total grain output in the whole year will reach a new high, the pig production capacity will be released, the pig production will return to the perennial level, and the production of cattle, sheep and poultry will remain stable; The market supply of major agricultural products is sufficient, the producer prices of agricultural products have steadily declined, and agricultural production has generally maintained a steady and progressive development trend.

  First, the total grain output has been above 1.3 trillion Jin for seven consecutive years.

  In 2021, China’s total grain output reached 1,365.7 billion Jin, a record high, an increase of 26.7 billion Jin or 2.0% over the previous year, and remained above 1.3 trillion Jin for seven consecutive years. The grain sown area has increased for two consecutive years, and the national grain sown area is 1.764 billion mu, an increase of 12.95 million mu or 0.7% over the previous year.

  Second, the output of pigs, cattle, sheep and poultry continued to increase.

  In 2021, the national output of pigs, cattle, sheep and poultry was 88.87 million tons, an increase of 12.48 million tons or 16.3% over the previous year. The output of pork increased substantially, the output of beef, sheep and poultry increased steadily, the output of milk increased rapidly, and the output of poultry and eggs decreased.

  In 2021, 671.28 million pigs were slaughtered nationwide, an increase of 27.4% over the previous year; The output of pork was 52.96 million tons, an increase of 28.8%. By the end of 2021, there were 449.22 million live pigs in China, up 10.5% year-on-year, of which 43.29 million were fertile sows, up 4.0% year-on-year, reaching 101.7% and 96.8% at the end of 2017 respectively.

  In 2021, 47.07 million beef cattle were slaughtered nationwide, an increase of 1.42 million over the previous year, an increase of 3.1%; The beef output was 6.98 million tons, an increase of 250,000 tons or 3.7%; The milk output was 36.83 million tons, up by 7.1%. By the end of 2021, the number of beef cattle in China was 98.17 million, a year-on-year increase of 2.7%. In 2021, 330.45 million sheep were slaughtered nationwide, an increase of 3.5% over the previous year; The output of mutton was 5.14 million tons, up by 4.4%. By the end of 2021, there were 319.69 million sheep in China, a year-on-year increase of 4.3%.

  In 2021, 15.74 billion poultry were slaughtered nationwide, an increase of 1.1% over the previous year; The output of poultry meat was 23.8 million tons, an increase of 0.8%; The output of poultry eggs was 34.09 million tons, down by 1.7%. By the end of 2021, there were 6.79 billion poultry in China, a year-on-year increase of 0.1%.

  Third, the producer prices of agricultural products are generally stable.

  In 2021, the total producer price level of agricultural products in China decreased by 2.2% compared with the previous year.

  Don’t look at the classification, driven by the sharp drop in the price of live pigs, the price of producers of raised animals and their products decreased by 17.9% in 2021 compared with the previous year; Producer prices of agricultural, forestry and fishery products rose by 10.6%, 2.4% and 8.8% respectively. In terms of varieties, with the continuous increase in the supply of live pigs, the producer price of live pigs decreased by 35.1% in 2021 compared with the previous year; The prices of corn and soybean increased by 25.5% and 12.8% respectively, and the increase rate dropped quarter by quarter; Wheat prices rose by 6.6%, rice prices rose slightly by 1.9%, and vegetable prices rose by 5.6%.

  Remarkable achievements have been made in ensuring energy supply.

  Hu Hanzhou, Director of Energy Statistics Department of National Bureau of Statistics

  In 2021, with the active promotion of peak carbon dioxide emissions and carbon neutrality in China, with the vigorous promotion of a series of policies and measures, such as stable energy supply and price, and dual control of energy consumption, China’s energy supply has achieved remarkable results and production has grown steadily, providing a strong guarantee for the sustained and stable recovery of the national economy and meeting the needs of people’s livelihood; The development of green and low-carbon energy has been solidly promoted, energy consumption has declined quarter by quarter, energy structure has been continuously optimized, and energy consumption intensity has remained declining.

  I. Steady growth of energy production

  In 2021, energy production enterprises thoroughly implemented the task of ensuring supply, energy production increased steadily, and the capacity of safe supply was further enhanced.

  Raw coal production continued to grow. In the face of tight coal supply and sharp price increase, coal production enterprises have made every effort to increase production and supply, accelerate the release of high-quality production capacity, and effectively ensure the people’s safe and warm winter and stable economic operation. The annual output of industrial raw coal above designated size was 4.07 billion tons, an increase of 4.7% over the previous year, an increase of 5.6% over 2019, and an average increase of 2.8% in two years.

  Oil and gas production grew steadily. Oil and gas production enterprises continue to increase exploration and development efforts, promote increased reserves and production, and strive to ensure economic and people’s livelihood with oil and gas. The annual output of industrial crude oil above designated size was 198.98 million tons, an increase of 2.4% over the previous year, an increase of 4.0% over 2019, and an average increase of 2.0% in two years; The output of natural gas was 205.3 billion cubic meters, up by 8.2% over the previous year, with an increase of over 10 billion cubic meters for five consecutive years, up by 18.8% over 2019, with an average increase of 9.0% in two years. The processing capacity of crude oil exceeded 700 million tons, up 4.3% over the previous year, up 7.4% over 2019, and up 3.6% on average in two years.

  Power production grew rapidly. Power production enterprises adhere to the people’s livelihood priority, strive to improve the level of power supply, and fully protect the economic and people’s livelihood electricity demand.

  The annual power generation of industrial enterprises above designated size exceeded 8 trillion kWh, an increase of 8.1% over the previous year, an increase of 11.0% over 2019, and an average increase of 5.4% in two years. In terms of power supply, thermal power increased by 8.4%, hydropower decreased by 2.5%, nuclear power increased by 11.3%, wind power increased by 29.8% and solar power increased by 14.1%.

  2. Imports of coal and natural gas increased rapidly, while imports of crude oil declined.

  According to the express data of the General Administration of Customs, the coal import in 2021 was 320 million tons, an increase of 6.6% over the previous year; Crude oil imports were 510 million tons, down 5.4% from the previous year; Natural gas imports reached 120 million tons, up by 19.9% over the previous year.

  Third, energy consumption fell quarter by quarter.

  In 2021, the growth rate of energy consumption showed a downward trend quarter by quarter due to factors such as double control of energy consumption, the blind development policy of resolutely curbing the "two high" projects and the rise of the base in the same period. According to preliminary calculations, the total energy consumption in the whole year increased by 5.2% over the previous year, and the growth rate dropped by 9.4, 5.3 and 2.1 percentage points respectively compared with the first quarter, the first half and the first three quarters. Average growth of 3.7% in two years. The energy consumption of industrial enterprises above designated size, which accounts for more than 60% of the energy consumption of the whole society, increased by 3.5%, dropping by 11.0, 6.6 and 2.5 percentage points respectively compared with the first quarter, the first half and the first three quarters.

  Fourth, the energy consumption structure continued to be optimized

  According to preliminary calculations, in 2021, the proportion of clean energy consumption such as natural gas, hydropower, nuclear power, wind power and solar power generation in total energy consumption increased by 1.0 percentage points over the previous year, while the proportion of coal consumption decreased by 0.8 percentage points.

  5. The intensity of energy consumption keeps declining.

  According to preliminary calculations, in 2021, the energy consumption per unit GDP will decrease by 2.7% compared with the previous year, and the energy consumption per added value of industrial units above designated size will decrease by 5.6%.

  The profits of industrial enterprises increased rapidly.

  Lu shan, Director of Industrial Statistics Department of National Bureau of Statistics.

  In 2021, the "six guarantees" and "six guarantees" were solidly promoted, and industrial production progressed steadily.

  I. Stable recovery of industrial production

  Industrial production grew steadily. In 2021, the added value of industrial enterprises above designated size increased by 9.6% over the previous year, and the growth rate was 6.8 percentage points faster than that in 2020.

  The three categories grew rapidly. In 2021, the added value of mining, manufacturing, electricity, heat, gas and water production and supply industries increased by 5.3%, 9.8% and 11.4% respectively compared with the previous year, all of which achieved rapid growth.

  Most industries and products have increased compared with 2019. In 2021, among the 41 major industries, 39 industries increased over the previous year. Among 612 industrial products, the output of 450 products increased year-on-year.

  The capacity utilization rate has reached a new high in recent years. In 2021, the national industrial capacity utilization rate was 77.5%, up 3.0 percentage points from 2020 and 0.9 percentage points from 2019, the highest level in recent years.

  II. Steady progress was made in industrial transformation and upgrading.

  The production of equipment manufacturing industry has risen steadily. In 2021, the added value of equipment manufacturing industry increased by 12.9% over the previous year, which was 3.3 percentage points higher than the average level of all industries above designated size, and contributed 45.0% to the growth of all industries above designated size. High-tech manufacturing industry maintained rapid growth. In 2021, the added value of high-tech manufacturing industry increased by 18.2% over the previous year, 8.6 percentage points higher than the average level of all industries above designated size, and the contribution rate to the growth of industries above designated size was 28.6%.

  Third, the rapid growth of industrial exports

  Thanks to China’s relatively complete industrial chain and supply chain, the export of industrial products has continued to grow rapidly. In 2021, export delivery value, an industrial enterprise above designated size, increased by 17.7% over the previous year and decreased by 0.3% in 2020; The average growth rate in two years is 8.3%, which is a higher level in normal years in recent years.

  Four, corporate profits to maintain a high level.

  Corporate profits maintained rapid growth. From January to November 2021, the profits of industrial enterprises above designated size increased by 38.0% year-on-year, with an average increase of 18.9% in two years, and the growth rate continued at a high level. Among the 41 major industries, 33 industries achieved year-on-year growth in profits.

  The structure of profit industry has improved. In November, the prices of some commodities fell, and the contribution of consumer goods manufacturing and equipment manufacturing to industrial profits increased. The total proportion of profits in industries above designated size reached 57.4%, and the proportion increased significantly, and the structure tended to improve.

  V. Stable recovery of small and micro enterprises

  The overall production of small and micro enterprises continued a good trend of stable recovery. According to the survey, in the fourth quarter of 2021, the proportion of small and micro enterprises with good production and operation conditions and average enterprises accounted for 81.7%, up by 3.9 percentage points over the same period of the previous year. In the fourth quarter of 2021, the proportion of small and micro enterprises enjoying preferential tax policies was 62.3%.

  The stabilizer of service industry plays an obvious role

  Li Suoqiang, Director of Service Industry Survey Center of National Bureau of Statistics

  In 2021, the service industry economy showed strong resilience, new kinetic energy showed vigorous vitality, and the happiness industry improved people’s livelihood and well-being, maintaining a recovery growth trend throughout the year.

  First, the service industry achieved a good start

  The "stabilizer" of service industry plays an obvious role. According to preliminary accounting, the added value of service industry in 2021 was 60,968 billion yuan, an increase of 8.2% over the previous year. The added value of service industry accounted for 53.3% of GDP, and contributed 54.9% to economic growth, driving GDP growth by 4.5 percentage points.

  The production and operation of enterprises have resumed steadily. In December 2021, the national service industry production index increased by 3.0% year-on-year, with an average growth of 5.3% in two years.

  Investment in service industry continued to expand. In 2021, the investment in fixed assets in the service industry increased by 2.1% over the previous year; The actual use of foreign capital in the service industry was 906.49 billion yuan, up 16.7% year-on-year, accounting for 78.9% of the actual use of foreign capital in the country.

  Trade in services maintained rapid growth. From January to November 2021, the total import and export volume of China’s service trade was 4,676.78 billion yuan, a year-on-year increase of 14.7%; Service exports were 2,236.44 billion yuan, up 31.5% year-on-year, and service imports were 2,440.34 billion yuan, up 2.6% year-on-year.

  Second, the development of new kinetic energy is stable.

  The new kinetic energy of the service industry continues to stimulate. In 2021, the added value of information transmission, software and information technology services and financial industry increased by 17.2% and 4.8% respectively over the previous year, which together boosted the added value of service industry by 1.9 percentage points.

  The new service industry has developed vigorously. Cutting-edge technologies such as 5G, artificial intelligence, and virtual reality are accelerating integration with more service industry scenarios in practice, helping to upgrade commodity consumption and upgrade service consumption.

  Industrial integration continued to deepen. The new generation of information technology expands the space of digital transformation, and the manufacturing industry and service industry continue to integrate and promote each other.

  The development momentum of key service industries is good. In 2021, the investment in fixed assets of high-tech service industry increased by 7.9% over the previous year, which was 5.8 percentage points higher than the investment in fixed assets of all service industries. In 2021, the actual use of foreign capital in high-tech service industry increased by 19.2% year-on-year.

  Third, the happiness industry focuses on people’s livelihood expectations

  The happiness industry has developed rapidly. From January to November 2021, the operating income of service industry, health and social work enterprises of residents above designated size increased by 20.7% and 18.0% respectively. Among them, family services and hospital operating income increased by 18.2% and 17.1% respectively. From January to November, 2021, the operating income of cultural, sports and entertainment enterprises above designated size increased by 23.8% year-on-year, which was 3.1 percentage points faster than that of service enterprises above designated size.

  Fourth, the development prospects of the service industry can be expected

  The service industry maintained an expanding trend. In December 2021, the business activity index of the service industry was 52.0%, up 0.9 percentage points from November, and the pace of business activity recovery of the service industry was generally accelerated. Holiday consumption highlights development advantages. There are many highlights in the New Year’s Day holiday in 2022. The "good start" of the New Year reflects the vitality of China’s consumer market and the potential of domestic demand market.

Empowering the "Flying Whale Sports Data" of the third-party platform with sports data, hoping to let users know the events in all directions.

With the four-year World Cup in full swing, "watching live" has become the primary entertainment for many young people after work. However, in addition to the competition itself, the data during the competition is also the focus of users’ attention.
36Kr recently came into contact with the SaaS-based sports data service system "Flying Whale Sports Data" (formerly known as scouting sports data), hoping to meet the data requirements for sports media, live events, data analysis and other sports products.
Flying Whale Sports Data belongs to Zhaoqing Huaying Sports Culture Development Co., Ltd. (hereinafter referred to as Huaying Sports), a sports content producer and data provider. Huaying Sports has eight sections, such as scouting network, scouting recommendation and watching day. The products provide users with real-time analysis of various sports events and relevant information of the event content. Users can also post posts and participate in discussions in the sports social club.
Huaying sports product matrix
As a data platform launched by Huaying Sports, Flying Whale Sports Data mainly provides paid data services for third-party platforms by providing interfaces. At present, its products include real-time data (scores of various events, fouls, technical statistics, etc.), live animated text, race results, historical information of events (World Cup, Premier League, NBA, etc.) and other sports-related data; At the same time, the platform can also provide sports lottery related index data, including national sports lottery data and odds. In addition, the platform will soon be online e-sports and other data.
Flying Whale Sports Data tells 36Kr that as the main project of the platform, its football data products have covered 2 million+events in 200+ countries and regions.
Huaying Sports was founded in 2006. Peng Lingzhe, deputy general manager of Huaying Sports, told 36Kr that the company has provided professional sports data for B-end users since its establishment, and self-operated C-end products such as scouting network are also verifying and using its data. With the arrival of the World Cup in Russia and the increasing attention of users to sports data, Huaying Sports has launched flying whale sports data after integrating a number of data services.
It is worth mentioning that in order to strengthen the timeliness, accuracy and stability of data, Flying Whale Sports Data has established a "7*24*365" operation and maintenance team to provide data guarantee for customers.
in additionIn order to meet the needs of different customers, Flying Whale Sports Data will customize product solutions for different product types such as sports media, live events and data analysis. At the same time, customers can use this key update. SaaS service platform, complete online product management, real-time update of technical documents and other functions.
Customer background interface of flying whale data
Peng Lingzhe said that "a large number of data sources+exclusive authorization" of flying whale sports data is its main barrier, and the technical service accumulated by scouting network for many years can ensure the stability of data and the rapid response to sports information. "At present, the platform data is mainly based on machine monitoring, assisted by personnel participation, and we also have a data center team to provide real-time protection for customers".
Flying whale sports data mainly collects data usage fees from B-end users on a monthly/annual basis.Peng Lingzhe said, "The price is determined according to the scale of customer data collection, and combined with the number of data types. At present, a large number of customers have been accumulated, and the products have achieved profitability. The partners include Know the Ball Emperor and A8 Sports. Now we have a high threshold for customers, and we will provide customized services for small customers in the future, lowering the threshold. According to the platform planning, we will also launch game prediction services in combination with machine learning and big data. "
It is understood that Huaying Sports won the strategic investment of IDG Capital in 2011, but the specific amount was not disclosed.
Flying whale sports data competition includes sports data provider Radar Sports, which develops nested data for lottery companies based on the original data of Sportradar XML. At the same time, the company has four products: data live broadcast, statistical center, game analysis and text live broadcast.
I’m Liu Shiwu, the author of 36Kr. I’m concerned about cutting-edge technology, AI, travel and entertainment. Please add liushiwude on WeChat and indicate the company+position+reason. Thank you!
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The key choice in the new era: a major strategic task related to China’s overall development

  During the National Day holiday, the tourists in the scenic spot are like weaving, and the business of merchants is booming, showing the great potential of China’s super-large-scale market; At the port and dock, huge ships shuttle back and forth, and the bridge crane operation is busy, which shows China’s firm determination to build a new open economic system at a higher level — — Today’s China is speeding up on the road of building a new development pattern.

  Standing at the historical intersection of the goal of "two hundred years", the CPC Central Committee with the supreme leader as the core has made overall plans for the great rejuvenation strategy of the Chinese nation and the unprecedented changes in the world in the past century, made a major strategic decision to accelerate the construction of a new development pattern, and made clear the path choice of China’s economic modernization, which is of great and far-reaching significance for promoting China’s high-quality development and promoting world economic prosperity.

  This is a strategic choice to keep pace with the times and improve the level of China’s economic development, as well as to shape China’s new advantages in international economic cooperation and competition.

  It requires extraordinary strategic determination, superb strategic thinking and scientific strategic decision-making to raise the flag and steer the ship. General Secretary of the Supreme Leader personally planned, deployed and promoted, and a magnificent picture of accelerating the construction of a new development pattern is being fully rolled out in China, leading China’s economy to stride forward on a new journey.

  Strive to take the lead in the crisis and start a new game in the changing situation.

  On January 11 this year, the Central Party School (National School of Administration). General Secretary of the Supreme Leader gave the "First Lesson of Opening the Year" to more than 190 students from various provinces, autonomous regions and municipalities, Xinjiang Production and Construction Corps, relevant departments of central and state organs, relevant people’s organizations, major military units and various departments of the Central Military Commission.

  General Secretary of the Supreme Leader profoundly pointed out: "It is ‘ Fourteenth Five-Year Plan ’ Planning a major strategic task proposed in the "Proposal" that is related to China’s overall development needs to be accurately grasped and actively promoted from the overall situation. "

  The strategic issue is the fundamental issue of a political party and a country. The General Secretary of the Supreme Leader emphasized: "Accelerating the construction of a new development pattern is a strategic measure for us to grasp the initiative of future development, to enhance our viability, competitiveness, development and persistence in all kinds of foreseeable and unpredictable storms, and it is a tough battle and a protracted war that needs to maintain tenacious fighting spirit and strategic strength. We should consciously incorporate the work of our local departments into the construction of a new development pattern, make overall consideration and planning, and take more firm ideological consciousness, precise and pragmatic measures, and really get down to work."

  The clock was turned back to the beginning of 2020, and a once-in-a-century epidemic hit hard. At that time, China’s economy was in the key period of changing the development mode, optimizing the economic structure, and transforming the growth momentum. The economic development prospects were improving, but it was also faced with difficulties and challenges brought about by the interweaving of structural, institutional and cyclical problems. In addition, the economic operation was under great pressure due to the impact of the epidemic.

  In the unprecedented historical examination, as a developing country with a population of more than 1.4 billion, it is faced with multiple tasks and difficult choices. General Secretary of the Supreme Leader firmly pointed out: "We must persist in analyzing the current economic situation with a comprehensive, dialectical and long-term perspective, and strive to cultivate new opportunities in the crisis and open up new opportunities in the changing situation."

  Insight into the time and situation, grasp the danger and opportunity. On April 10, 2020, at the seventh meeting of the Central Financial and Economic Committee, the General Secretary of the Supreme Leader delivered an important speech on the topic of "Several Major Issues of the National Medium-and Long-term Economic and Social Development Strategy", and put forward the important idea of building a new development pattern for the first time.

  This is a profound grasp of the great change that has never happened in the world in a century: "The world today is experiencing a great change that has never happened in a century. The global epidemic of COVID-19 epidemic has accelerated the evolution of this great change, economic globalization has encountered countercurrent, protectionism and unilateralism have risen, the world economy has been in a downturn, international trade and investment have shrunk dramatically, the international economy, science and technology, culture, security and politics have all undergone profound adjustments, and the world has entered a period of turbulent change."

  This is the overall planning of the great rejuvenation strategy of the Chinese nation: "China is in a critical period to realize the great rejuvenation of the Chinese nation, and the economy has shifted from a high-speed growth stage to a high-quality development stage. The main contradictions in our society have changed, the people’s demands for a better life have been continuously improved, the economy has been improving for a long time, the market space is vast, and the development resilience is strong. A new development pattern is being formed with the domestic big cycle as the main body and the domestic and international double cycles promoting each other. "

  Look at the general trend and seek the overall situation. Focusing on accelerating the construction of a new development pattern, General Secretary of the Supreme Leader delivered a series of important speeches and made a series of important instructions.

  The two national conferences in 2020 were successfully held in the eyes of the public. When visiting the economic members of the CPPCC, General Secretary of the Supreme Leader pointed out, "Facing the future, we should take meeting domestic demand as the starting point and the end result of development, and speed up the construction of a complete domestic demand system" and "gradually form a new development pattern with the domestic macro-cycle as the main body and the domestic and international dual cycles promoting each other, and cultivate new advantages for China to participate in international cooperation and competition under the new situation".

  In September 2020, General Secretary of the Supreme Leader pointed out at the symposium of grassroots representatives: "We should scientifically analyze the situation, grasp the general trend of development, adhere to the general tone of striving for progress while maintaining stability, adhere to the new development concept, make overall plans for development and security, and accelerate the formation of a new development pattern with the domestic big cycle as the main body and the domestic and international double cycles promoting each other."

  In October 2020, General Secretary of the Supreme Leader stressed during his inspection tour in Guangdong: "In the face of the unprecedented changes in the world and the profound and complicated changes in the development environment at home and abroad, we should take a higher level of self-reliance, implement a higher level of reform and opening up, and accelerate the construction of a new development pattern with the domestic big cycle as the main body and the domestic and international double cycles promoting each other."

  … … … …

  One far-sighted judgment, one decision after another to assess the situation, and one sentence of hit the floor’s words condense the profound insight and accurate grasp of the overall development of the leaders of big parties and powers.

  The autumn wind is cool and the fruits are fragrant. From October 26th to 29th, 2020, the Fifth Plenary Session of the 19th Central Committee of communist party, China was held in Beijing. "Speeding up the construction of a new development pattern with the domestic macro-cycle as the main body and the domestic and international dual-cycle promoting each other" was written in the Central Committee of the Communist Party of China’s Proposal on Formulating the 14th Five-year Plan for National Economic and Social Development and the Long-term Target for 2035.

  General Secretary of the Supreme Leader pointed out: "In recent years, with the changes in the global political and economic environment, the trend of anti-globalization has intensified, and some countries have engaged in unilateralism and protectionism, and the traditional international cycle has obviously weakened. In this case, we must put our development foothold at home and rely more on the domestic market to achieve economic development. China has a population of 1.4 billion, and its per capita GDP has exceeded 10,000 US dollars. It is the largest and most potential consumer market in the world, with huge room for growth. Since the reform and opening up, we have encountered many external risk shocks, and ultimately we can save the day, relying on doing our own thing well and putting our development foothold at home. "

  If you follow the path, you can achieve far-reaching goals. Accelerating the construction of a new development pattern is an initiative, not a passive response. It is a long-term strategy, not an expedient measure. It fully embodies the overall planning of the "two overall situations" by the CPC Central Committee with the Supreme Leader as the core, and the correct grasp and practical application of the objective laws of economic development, which has become the only way to promote China’s economic modernization and the first move to grasp the initiative of development.

  The development of the new era and new stage must implement the new development concept and must be high-quality development.

  "Based on the new development stage, implementing the new development concept, building a new development pattern and promoting high-quality development are the tasks that the whole party and the whole country must pay close attention to at present and in the future." Accelerate the construction of a new development pattern, and the General Secretary of the Supreme Leader is always awake at night, thinking about it — —

  Jiangsu, Anhui, Fujian, Hunan, Guangdong, Guangxi, Guizhou, Xizang, Shaanxi, Qinghai … … The General Secretary of the Supreme Leader’s inspection footprint spans the north and south of the river, and he has made a series of important arrangements for accelerating the construction of a new development pattern by going to the grassroots level, seeing enterprises, entering the fields and visiting farmers.

  From Politburo meeting of the Chinese Communist Party to the meeting of the Central Committee for Deep Reform, from the fifth plenary session of the 19th CPC Central Committee to the fourth session of the 13th National People’s Congress, the "14th Five-Year Plan" and the outline of the long-term goal in 2035 … … The CPC Central Committee with the Supreme Leader as the core has comprehensively promoted the major strategic task of accelerating the construction of a new development pattern.

  Entering the new development stage has defined the historical position of China’s development, and we must scientifically grasp the new development stage to build a new development pattern. General Secretary of the Supreme Leader pointed out: "Entering the new stage of development, profound changes in the domestic and international environment have brought a series of new opportunities as well as a series of new challenges, which are the coexistence of crises, the organic nature of crises and the turning point of crises."

  "Smart brain" unified scheduling, one production line ran out of the acceleration … … In Chaozhou Sanhuan (Group) Co., Ltd., a piece of ceramic refraction technology was upgraded. In October 2020, General Secretary of the Supreme Leader visited the company.

  "We propose to accelerate the formation of a new development pattern with the domestic big cycle as the main body and the domestic and international double cycles promoting each other. I hope that everyone can deeply understand the strategic intention of the CPC Central Committee, find their own position in the big strategic pattern, and make their own contributions to the country’s prosperity and socialist modernization." General Secretary of the Supreme Leader stressed.

  "The important speech of the General Secretary has made us fully aware of the new opportunities and challenges in the new stage of development. To seize the opportunities and meet the challenges, we must speed up the construction of a new development pattern and take a higher level of self-reliance." According to the relevant person in charge of Sanhuan Group, independent innovation has made enterprises taste the sweetness. In the first half of this year, the group’s revenue increased by 74.37% year-on-year.

  "Accurately recognize change, scientifically respond, actively seek change, be brave in sailing against the wind, and be good at turning crisis into opportunity". Facing the new stage and task of China’s development, the Supreme Leader General Secretary issued a call to accelerate the construction of a new development pattern — — On November 12, 2020, at the celebration meeting of the 30th anniversary of Pudong’s development and opening up, General Secretary of the Supreme Leader pointed out that Shanghai should "scientifically grasp the new development stage, resolutely implement the new development concept, serve and build a new development pattern, adhere to the general tone of striving for progress while maintaining stability, and be brave in picking the heaviest burden and gnawing at the hardest bones"; In November, 2020, when he visited Jiangsu, General Secretary of the Supreme Leader emphasized that Jiangsu should "strive to be a model in serving the whole country to build a new development pattern and take the lead in realizing socialist modernization" … …

  Implementing the new development concept has clarified the guiding principles of China’s modernization drive, and we must unswervingly implement the new development concept to build a new development pattern. General Secretary of the Supreme Leader stressed: "Whether the development concept is right or not fundamentally determines the development effectiveness and even success or failure." "The new development concept is a whole, which must be understood and implemented completely, accurately and comprehensively, and strive to serve and integrate into the new development pattern."

  The Yangtze River flows endlessly, and in the Nantong section of Jiangsu Province, the Chengjiang River seems to be practicing, and the grass is green. On the afternoon of November 12, 2020, General Secretary of the Supreme Leader came to the Yangtze River and made an on-the-spot inspection in Binjiang District, Wushan District, Nantong City, Jiangsu Province.

  "The General Secretary attaches great importance to the construction of ecological civilization. Under the guidance of the new development concept, we should do our best to protect ‘ Mother River ’ 。” Cheng Bin, director of the management office of Langshan Tourism Resort in Nantong City, remembers the scene of the day vividly.

  From the Yangtze River to the Jiuqu Yellow River, from the vast fields to the factory workshops, all regions and departments unswervingly implement the new development concept of innovation, coordination, green, openness and sharing, and show greater achievements in service and integration into the new development pattern.

  Promoting high-quality development is the theme of economic and social development during the 14 th Five-Year Plan period. To build a new development pattern, we must promote high-quality development. The General Secretary of the Supreme Leader pointed out: "It must be emphasized that the development of the new era and new stage must implement the new development concept and must be high-quality development."

  Entrepreneurs are an important subject of economic activities. On July 21, 2020, General Secretary of the Supreme Leader emphasized at the entrepreneurs’ forum: "Entrepreneurs must constantly improve themselves in patriotism, innovation, honesty, social responsibility and international vision, and strive to become a new force in building a new development pattern, building a modern economic system and promoting high-quality development in the new era."

  "The enthusiasm of the General Secretary has become a powerful driving force for us to strive for high-quality development. In the process of building a new development pattern, enterprises must achieve a high level of self-reliance." After listening to the important speech of the General Secretary at the forum, Ning Gaoning, chairman of China Sinochem, was filled with emotion.

  Take the first step and see a new atmosphere.

  Xiong’an new area, the "city of the future", is growing at jointing stage; Shanghai Pudong, Zhangjiang High-tech Park, vibrant generate; Shenzhen Special Economic Zone, the construction of the first demonstration zone has been fully rolled out and advanced in depth … …

  Take the first step and see a new atmosphere. In the first year of the 14 th Five-Year Plan, all regions and departments actively explored and took the initiative to take solid steps to build a new development pattern.

  The key to building a new development pattern lies in the unimpeded economic cycle. General Secretary of the Supreme Leader stressed: "We must persist in deepening the supply-side structural reform and continue to complete ‘ Three go, one drop and one supplement ’ The important task is to comprehensively optimize and upgrade the industrial structure, enhance innovation capability, competitiveness and comprehensive strength, enhance the toughness of the supply system, form a more efficient and higher quality input-output relationship, and achieve a dynamic balance of the economy at a high level. "

  The maximum mileage exceeds 1000 kilometers, and the acceleration is as fast as 2.9 seconds … … In September, BYD officially released the pure electric platform "E Platform 3.0". "With the continuous advancement of supply-side structural reforms, product technology and quality are greatly improved." The relevant person in charge of BYD Group said.

  The "14th Five-Year Plan" started, and all localities and departments concentrated their efforts on deepening the structural reform of the supply side, opening up the domestic large-scale circulation and domestic and international double-cycle blockage points, providing sustained impetus for economic development.

  The most essential feature of building a new development pattern is to achieve a high level of self-reliance. General Secretary of the Supreme Leader pointed out: "We must put more emphasis on independent innovation, comprehensively strengthen the deployment of scientific and technological innovation, pool superior resources, and vigorously and orderly promote innovation research ‘ Reveal the list ’ Institutional mechanisms to strengthen the docking between innovation chain and the industrial chain. "

  In the "smart workshop" of Shanhe Intelligent Equipment Co., Ltd., intelligent equipment such as automatic tightening machine and underframe turnover machine have shown their talents, and the production time of excavators has been reduced from 70 minutes to about 30 minutes.

  "With the increasing instability and uncertainty in today’s world, we must build a new development pattern and build a manufacturing power. The key core technologies must be firmly in our own hands, and the manufacturing industry must also be in our own hands." On the afternoon of September 17th, 2020, General Secretary of the Supreme Leader came to the company’s production workshop to inspect the equipment manufacturing process, understand the technology research and development, manufacturing and express his appreciation for their innovative spirit.

  "We remember General Secretary ‘ Key core technologies must be firmly in our own hands ’ The important instructions have overcome a series of technical problems. " He Qinghua, chairman of the company, said.

  Innovation is the first driving force for development. In the first three quarters, the added value of high-tech manufacturing and equipment manufacturing above designated size increased by 20.1% and 16.2% respectively, which was 8.3 and 4.4 percentage points higher than that of all industries above designated size.

  To accelerate the construction of a new development pattern, we must firmly grasp the strategic basis of expanding domestic demand. General Secretary of the Supreme Leader stressed: "To build a new development pattern, we must adhere to the strategic basis of expanding domestic demand, so that production, distribution, circulation and consumption rely more on the domestic market and form a virtuous circle of the national economy."

  This National Day holiday, Sanya International Duty Free City is very lively. "Thanks to the continuous improvement of measures to expand domestic demand, China has ushered in new important opportunities." According to the relevant person in charge of China Free Group, in the first half of this year, the operating income of Sanya International Duty Free City increased by about 210.01% year-on-year.

  Since the beginning of this year, various regions and departments have taken various measures to unswervingly promote consumption and stabilize investment. The contribution rate of domestic demand to economic growth in the first half of the year reached 80.9%.

  The new development pattern is by no means a closed domestic cycle, but an open domestic and international dual cycle. The General Secretary of the Supreme Leader pointed out: "It is necessary to shape China’s new advantages in participating in international cooperation and competition, attach importance to improving the efficiency and level of domestic large-scale circulation with international circulation, improve the quality and allocation level of China’s production factors, and promote China’s industrial transformation and upgrading."

  In mid-October this year, the ORIX viaduct gantry machining center brought by Spanish Nicolas crea Group has arrived in Shanghai Port and will be unveiled at the 4th China International Import Expo(CIIE). "Our sales in China increased from 200 million yuan in 2018 to 600 million yuan this year." Che Hangbiao, sales director of Group (Asia) Company, told the reporter.

  The negative list of cross-border service trade in Hainan Free Trade Port was issued, giving the Pilot Free Trade Zone greater reform autonomy in trade and investment facilitation … … Opening the door wider and wider will not only promote China’s sustained and stable economic recovery, but also inject new momentum into global economic recovery and growth.

  "The fundamentals of China’s stable and long-term economic development have not changed. We will scientifically grasp the new stage of development, firmly implement the new development concept, and actively build a new development pattern. " On the new journey, we should unite more closely around the CPC Central Committee with the supreme leader as the core, accurately grasp and actively promote the major strategic task of accelerating the construction of a new development pattern, and create a new and greater miracle that will impress the world!

Zero Run wants to replicate the success of LI in the market below 200,000 yuan.

With an annual sales volume of 376,000 vehicles and an annual revenue of more than 100 billion yuan, LI is firmly in the first place in the new force of car-making in 2023. Its imitator, Zero Run Auto, tried to segment the market under 200,000 yuan dominated by BYD and copied it successfully with the same strategy.

On March 2nd, Zero Run released the first global model C10, with a starting price of 128,800 yuan. This product is as close as possible to LI L series models from the interior design to the announcement and tone setting. At the press conference, Zero Run called this car "a more ideal home for young people".

Zhu Jiangming, CEO of Zero Run Auto, said in an interview with interface news and other media that every detail of Zero Run C10 is like the ideal L7 learning, and we can understand its subtleties such as grasping the user’s needs, the comfort of control and the display mode of the car.

Learning the experience of successful people can avoid some "traps" that are difficult to notice when developing products. Especially in the passenger car market with BYD’s pricing power of less than 200,000 yuan, the zero-running car facing the competition needs to provide products without obvious shortcomings and prices that attract users’ attention in order to win more market share.

The zero-run C10 is a medium-sized SUV, but the price of the entry-level and top-mounted models is lower than that of the compact SUV BYD Song PLUS DM-i by 1000 yuan. Zhu Jiangming believes that the zero run C10 at least targets BYD Tang, who is also a medium-sized SUV. The latter starts at 179,800 yuan.

This new car is also equipped with Qualcomm 8295 intelligent cabin chip, NVIDIA Orin X intelligent driving chip and laser radar, and the above hardware is generally equipped with products of more than 200,000 yuan.

By providing products with larger space size and higher configuration, but setting the price of lower-level models, the zero-run car has shaped the "cost-effective" label to the outside world.

However, the risk of the practice of "high allocation and low price" is that it is difficult for the company to obtain a better profit level, and it is necessary to form a large-scale sales volume to share the cost. In the third quarter of 2023, the net loss of zero-running cars was about 986 million yuan, and the free cash flow was still negative.

Another way to reduce costs is to rely on technological innovation. Zhu Jiangming revealed that the pallet materials and completely modular design adopted by the CTC battery chassis integration technology developed by Zero Run Automobile can move the cost space of about 1,500 to 2,000 yuan. In addition, the technical scheme of global self-research of core components can also give zero-run cars a stronger voice in bargaining with suppliers.

Zero-run cars will also adjust sales channels, add 4S shop service centers, and reduce and eliminate supermarkets with poor benefits. New forces such as Krypton and Xpeng Motors are doing the same channel optimization, which can not only reach a wide range of sinking users, but also reduce the cost of building stores.

In addition to the C10, the models on sale of the zero-run car include the medium and large-sized car C01, the medium and large-sized SUV C11 and the mini-car T03. These three models have ushered in a change at the same time and the price has been lowered compared with before, ranging from 4,000 to 10,000 yuan.

Zhu Jiangming expects that this year’s sales ranking of zero-running cars will be at least one more among the new forces of car-making. In 2023, the annual sales volume of zero-run cars was 144,000, ranking third behind LI and Weilai cars.

BYD is one of the key factors that affect the achievement of the goal. Last year, this new energy vehicle sales champion with an annual sales volume of 300 vehicles maintained a gross profit margin of more than 20% for many quarters, which means that it has more room to reduce costs and fight price wars.

Changan Deep Blue and Geely Galaxy, which are backed by traditional factories, are aiming at the same market segment, and they have sufficient price reduction power and financial support to compete with zero-run cars for market share.

Overseas markets may provide some sales support. In the third quarter of this year, C10 and T03 will be exported to Europe one after another. Zhu Jiangming revealed that this year, Zero Car will develop more than 200 overseas sales outlets and achieve sales of 6,000 to 10,000 vehicles. Overseas models of retail cars will still be produced in China and shipped to Europe.

The "Provisions on Administrative Punishment for Price Violations" is welcome to be revised, which is of great significance to curb the killing of big data.

  On July 2, the State Administration of Market Supervision promulgated the Provisions on Administrative Punishment for Price Violations (Revised Draft for Comment) (hereinafter referred to as the "Provisions") for public comments.

  The Paper reporter noted that the Provisions on Administrative Punishment for Price Violations was approved by the State Council on July 10th, 1999, and was revised three times in 2006, 2008 and 2010. Compared with the previous version, the highlight of this revised draft for comments is the addition of "price violations in new formats".

  It is mentioned in this clause that in any of the following circumstances, a warning shall be given and the total sales of the previous year may be fined 1‰ The above 5 & permit; The following fines, illegal income, confiscate the illegal income; If the circumstances are serious, it shall be ordered to suspend business for rectification or revoke its business license.

  These situations include: e-commerce platform operators use big data analysis, algorithms and other technical means to set different prices for the same goods or services under the same trading conditions based on the preferences and trading habits of consumers or other operators and factors other than cost or legitimate marketing strategies. Commonly known as "big data killing."

  In addition, the price violations specified in this clause also include the dumping of e-commerce platform operators who do not have a dominant market position at a price lower than the cost through subsidies and other forms in order to crowd out competitors or monopolize the market, disrupting the normal production and operation order and harming the national interests or the legitimate rights and interests of other operators.

  Chen Wenming, a lawyer of Zhejiang Xiaode Law Firm, told The Paper that the Regulations on Administrative Penalties for Price Violations revised by the State Administration of Markets is to meet the needs of the economic development of the times, especially the economic development of Internet e-commerce.

  Multi-level laws and regulations regulate the killing of big data, with a total sales volume of 5‰ Fines and suspension of business for rectification have great deterrent power.

  At present, many laws and regulations have been promulgated to restrict the killing of big data, including the E-commerce Law, the Anti-monopoly Law and the Price Law. Different laws differ in punishment intensity, regulation scope and treatment cycle.

  Compared with the fine imposed by the E-Commerce Law, the Provisions on Administrative Penalties for Price Violations is relatively more deterrent.

  The first paragraph of Article 18 of the E-Commerce Law, which was officially implemented in January 2019, stipulates: "If an e-commerce operator provides search results of goods or services to consumers according to their hobbies, consumption habits and other characteristics, it should also provide the consumers with options that are not specific to their personal characteristics, and respect and equally protect the legitimate rights and interests of consumers."

  The "Electronic Commerce Law" imposes a maximum penalty of 500,000 yuan for violating this clause. However, the punishment standard for killing illegal big data in the Draft of Provisions is completely different, and it is proposed that the total sales of the previous year should be 1‰ The above 5 & permit; The following fine punishment measures, if the circumstances are serious, may even be ordered to suspend business for rectification, or revoke the business license.

  Liang Zheng, a professor at the School of Public Administration of Tsinghua University and secretary-general of the Academic Committee of the Tsinghua University Research Center for Science and Technology Development and Governance, told the The Paper that the usual punishment for price violations is to confiscate the illegal income or impose a fine several times the illegal income, and impose a 1 & permit; The above 5 & permit; The following fines are severe, with a strong punitive nature and a greater deterrent to enterprises.

  However, Liang Zheng believes that this penalty clause needs to be further clarified. For example, whether the total sales in the previous year refers to the previous year when the illegal act was implemented or the previous year when the regulatory agency initiated the investigation; Total sales refers to the total sales of the enterprise or the sales of the business or products involved in the illegal act.

  Liu Xu, a special researcher of Tsinghua University National Institute of Strategic Studies, expressed support for "suspending business for rectification and revoking marketing license". "For some platform companies, it is willing to spend hundreds of millions and billions to burn money. He doesn’t care about the millions of fines or tens of millions of fines, or even hundreds of millions of fines, because he can refinance." Liu Xu said, "So for such companies, the best way is to stop, or suspend business for rectification, or let it completely withdraw from this market."

  Compared with the lengthy enforcement cycle of the Anti-Monopoly Law, the Provisions on Administrative Punishment for Price Violations is more convenient in law enforcement.

  The clause in the Anti-Monopoly Law related to big data killing is Article 17, paragraph 6, which stipulates that "without justifiable reasons, different treatment is given to counterparties with the same conditions on trading conditions such as trading price", which constitutes an abuse of market dominance and should be prohibited. "The subject to which this clause refers is" an operator with a dominant market position ". This time, the "Regulations" will expand the main body to e-commerce platform operators.

  In addition to the expansion of the scope of application of the Regulations, Liu Xu also believes that the Anti-Monopoly Law has a long enforcement period and is difficult to prove. "From the perspective of price enforcement, the current Regulations are relatively simple and should be more convenient to implement. This is a positive place."

  It is difficult to prove that big data is cooked. What else needs to be done besides laws and regulations?

  The dimension of laws and regulations has clarified the crackdown and punishment on big data killing, and the dimension of daily supervision is also making efforts to solve the problem of difficult evidence collection for big data killing.

  Chen Wenming, a lawyer of Zhejiang Xiaode Law Firm, pointed out that the difficulty of big data supervision in the past was how to supervise algorithms. "The behavior of supervising big data killing is not simply to monitor the company, but to monitor the company’s algorithm. No Internet company will fully disclose its own algorithm, which is the biggest difficulty in supervising big data killing." He further explained that if you really want to supervise the killing behavior, you should supervise the algorithms of various enterprises and let them publish these algorithms, at least to the regulatory authorities, so that the regulatory authorities can have evidence to check. This is the first step for everyone to supervise these Internet companies.

  Liang Zheng, a professor at the School of Public Administration of Tsinghua University and secretary-general of the Academic Committee of Tsinghua University Science and Technology Development and Governance Research Center, also believes that big data is hidden, it is difficult to obtain evidence, and it is difficult to investigate and deal with it.

  Liang Zheng suggested that you can try the following regulatory tools:

  First, play the role of whistleblower. Encourage employees in peer companies or enterprises to actively report big data killing behavior and provide clues and evidence materials for regulators.

  Second, the use of big data monitoring technology to achieve smart supervision. Platform enterprises have the advantages of data, algorithm and technology, and there is an information gap between regulators and enterprises. Regulators can realize real-time monitoring through big data monitoring system.

  Third, cooperation between government and enterprises to achieve coordinated supervision. If the traditional antagonistic relationship between regulators and enterprises continues, platform governance can only become a "cat and mouse" game, which cannot effectively solve the problem of killing big data. The cooperation and cooperation between regulators and enterprises should be strengthened, and enterprises should be encouraged to be self-compliant. Regulators can require enterprises to provide internal compliance explanations or price policies to monitor the effect of their self-compliance.

  Some regions have made very valuable explorations. In March 2021, the "Zhejiang Fair Online" system, which was developed and built by Zhejiang Market Supervision Bureau, was launched for monopoly and improper behaviors in the platform economy.

  According to reports, "Zhejiang Fair Online" relies on the national online trading monitoring platform, and its monitoring scope covers major online trading platforms such as Taobao, Tmall, JD.COM, Pinduoduo, Meituan and Suning.cn. It can dynamically monitor the qualifications of platform economic operators, trading rules, brand goods, sales prices and other information in real time, and illegally implement operator concentration.

  The community group buying platform has been fined many times, and the Regulations have turned law enforcement experience into clear rules.

  In addition to regulating the killing of big data, another highlight of the Regulations is that in the section of "Price violations in new formats", "the price violations specified under this clause also include the dumping of e-commerce platform operators who do not have a dominant market position at a price lower than the cost through subsidies and other forms, disrupting the normal production and operation order and harming the national interests or the legitimate rights and interests of other operators" is clearly illegal.

  Since the beginning of this year, many community group buying platforms have been punished for allegedly dumping at low prices. In March, the General Administration of Market Supervision imposed administrative penalties on unfair price behaviors of five community group buying enterprises, among which illegal behaviors included "low-price dumping" behavior of selling goods below the purchase cost through huge subsidies. In May, the General Administration of Market Supervision imposed a fine of 1.5 million yuan on the 10th Club, and ordered the 10th Club platform in Jiangsu to suspend business for 3 days. After investigation, it was found that the 10th Club sold goods at a price lower than the purchase cost through huge subsidies.

  Therefore, in the view of Liu Xu, a special researcher of Tsinghua University National Institute of Strategic Studies, the Regulations have turned the law enforcement experience in the past six months into clear rules to guide enterprises and new formats. "It shows a clear position — — The State Administration of Markets clearly wants to strengthen the supervision of the platform economy. "

  Liu Xu believes that the successful experience of law enforcement of relevant departments in the first half of the year is to investigate and deal with price fraud and false propaganda in community group buying. This exposure draft will continue to strengthen the punishment for this type of behavior to a certain extent. "If you check it again, you will suspend business for rectification, and then the next step is to cancel your license. This will have a greater impact on platform enterprises.

  (This article is from The Paper, please download the "The Paper" APP for more original information)

The price is 56,900-70,900 yuan, and the 2017 Changan Auchan is listed.

  [New car on the market] A few days ago, we learned from relevant channels that the 2017 model was officially listed.The new car has five configurations, and the price range is 56,900-70,900 yuan.The guide price of some models has increased by 1000 yuan.

2017 Changan Auchan Guide Price car make and model Price (ten thousand yuan) 1.5L manual standard type 5.69 1.5L manual elite type 6.09 1.5L manual luxury model 6.59 1.5L manual zhilian type 6.69 1.5L manual distinguished type 7.09

Home of the car

  In terms of appearance, the biggest change of the 2017 model also comes from the appearance, mainly the adjustment of the front air intake grille style. The interior of the front grille adopts a black mesh style, and the chrome-plated bright bars that used to run through the middle mesh are moved below the LOGO, which makes the visual effect more exaggerated.

Home of the car

Home of the car

  Blue decoration is added inside the headlight group, which makes the visual effect more exquisite, and the appearance is basically the same as that of the current model in other aspects.

Home of the car

Home of the car

  There is no change in the interior, and it still enhances the overall feeling of the car for the embracing shape. In addition, the dual screen is still the biggest highlight in the car, which has improved the sense of grade in the car. The seats of the real-shot vehicle are still in the 7-seat layout of 2+3+2, and the second row can form a complete plane after being laid down, and the space utilization rate is still relatively high.

Home of the car

Home of the car

  In terms of configuration, the 2017 model has improved slightly. Among them, the roof rack appears as standard, and the main driver’s seat and mobile phone mapping function are added to other models except the standard one. The latest distinguished model is equipped with keyless entry, one-button start, online navigation, reversing image follow-up line, right image, green glass of the whole car, lumbar support and heating of the main driver’s seat, etc., and the configuration is more abundant.

Home of the car

Home of the car

  In terms of power, it is still equipped with the model DAM15B 1.5L, with a maximum of 114 horsepower and a peak value of 148 Nm, and the transmission system is matched with the fifth gear. (Text/car home Dong Liu)

The new invoicing tool "Tax UKEY" will meet you soon! Get to know this knowledge first.

1. How to adjust the invoice printing format by using tax Ukey?

Format adjustment of general VAT invoice: If it is the first time for installation and use, after issuing an invoice, click Issue and Print or click Invoiced to query and view the original invoice. On the original invoice page of VAT ordinary invoice, click "Print" and click

Icon, you can adjust the invoice printing format.

Adjustment of VAT roll invoice format: click the menu item System Settings/System Parameter Settings/Parameter Settings/Roll Invoice Configuration, and click Printer Settings to open the page margin setting window. Select a printer or adjust the page margins as needed, and then click OK.

The adjustment rules are that the ticket content needs to be moved to the left to reduce the left margin; Need to move to the right to increase the left margin; Need to move up to reduce the upper margin; Need to move down to increase the top margin. When adjusting the format of VAT ordinary invoice, if the face content needs to be adjusted to the left or right after adjustment according to this rule, but when the left margin is moved in the software, the content will not be printed completely, so it is necessary to move the position of the printer baffle. If the ticket content is printed to the left as a whole, how many printer baffles move to the left by the same distance.

2. What is the password of tax Ukey?

The password of tax UKey involves three passwords: the initial password of "tax UKey" is 8 8; The initial password of "Digital Certificate" is 8 8, which must be modified for the first login; "Administrator login password", which is set by yourself during installation initialization.

3. Prompt when using tax Ukey invoice to fill out: Failed to query the code number of VAT electronic ordinary invoice. What should I do?

It is recommended to verify whether the invoice has been collected and purchased. If the invoice has been collected and purchased, follow the following steps: invoice management-invoice collection and purchase management-invoice online distribution, and then fill in the invoice after distribution.

4. What are the addresses and ports of the Ukey billing software server? What are the format file addresses and ports of the electronic invoice configuration?

Server address: fpkj.chongqing.chinatax.gov.cn, port: 555.

Format file server address: fpkj.chongqing.chinatax.gov.cn, port: 666.

5. When using tax Ukey to issue VAT electronic ordinary invoice, you are prompted with the message "Please complete the catalog setting first". How to operate it?

Click Invoice Management-Positive Invoice Filling-VAT Electronic Ordinary Invoice to open the VAT Electronic Ordinary Invoice window. When you enter for the first time, you need to click the "Directory Settings" button, and the "Import Settings" window will pop up, where you can set the import file directory, backup file directory, result file directory and scanning interval, and then click the "Save" button.

6. Using tax Ukey to issue invoices, the message "You are downgrading the VAT invoicing software. According to the requirements of State Taxation Administration of The People’s Republic of China, this function is prohibited after downgrading. Please upgrade the tax classification code to at least the latest version 33.0 before continuing this operation" is prompted. What should I do?

Upgrade the commodity and tax code to version 33.0.

Click System Settings-Basic Coding Settings-Goods and Services Tax Classification Code to enter the Goods and Services Tax Classification Code window, where you can download and import the code data.

Seven, the first login prompt, error code 09D106-did not find the specified data, how to do?

If only one tax Ukey is inserted, and only one tax Ukey is in use on the computer, that is, the tax Ukey has not been issued, it is recommended to issue it in the tax hall where the company is registered.

8. How does the tax Ukey version of VAT invoice software change the name of the drawer?

Log in to the billing software as an administrator, click System Maintenance-System Maintenance Home-Operator Management, and click Operation Identity Management to see if there is a "02 Billing Agent":

1. If there is a "02 drawer", click "Operator Account Management" and "Add Operator", enter the information of the drawer, select the drawer as "Identity" and click "Save".

2. If there is no "02 drawer", you need to increase the drawer’s authority first. The operation steps of adding a drawer are as follows: system maintenance-operator management-new identity-input identity-permission assignment (set the authority as needed). After adding, click "operator account management" "add operator", enter the drawer’s information, select the drawer by "identity" and click "Save".

When logging out of the software and logging in again, select the name to log in when logging in, and the drawer is the displayed name.

9. Can you set letters and special symbols in the tax Ukey password?

It can only be 8 digits.

10. What is the number limit for the certificate password? Can I set letters and numbers?

Certificate password digits, 6-8 digits, letters and numbers can be set.

XI. When adjusting the printer format for VAT ordinary invoices, it is suggested that "the error between the paper height and the actual invoice paper height is too large". What should I do?

The user has modified the paper height when adjusting the invoice format. The default paper height is 140, so just change the paper height back to 140.

12. Where can I download the public service platform?

Open a web browser, enter https://inv-veri.chinatax.gov.cn in the address bar to open the "State Taxation Administration of The People’s Republic of China National Invoice Inspection Platform", and click Related Downloads → VAT Invoice Invoicing Software (Tax Ukey Edition) to download the installation package.

13. When logging in with Ukey, the message "Abnormal server connection, do you want to update with offline files?" is prompted. How to operate?

1. The computer network must be normal. 2. The computer time and date are normal. 3. Click the menu item "System Settings/System Parameter Settings/Parameter Settings/Network Configuration" to pop up the server address and port configuration window, check whether the server address is "fpkj.chongqing.chinatax.gov.cn" and the server port is changed to 555, click "Test Connection", and click "OK" at the bottom after success.

14. I have logged in the Ukey version of the billing software on one computer, and now I have to install the billing software on another computer. Do you want to reset the Ukey password, certificate password and administrator password?

Ukey password and certificate password need not be reset. (If the Ukey password has not been modified, enter the initial password with 8 digits, and verify the digital certificate password with the modified certificate password) The administrator password can be reset.

15. What should I do if the invoice cannot be uploaded normally after using tax Ukey invoicing software?

When the network is normal, the system will automatically upload the invoice after it is issued; This problem is caused by abnormal network, so taxpayers are advised to reset the server port. The operation path is: system setting-parameter setting-network configuration-server port "555"; If the port is already "555", the taxpayer needs to log in again after logging out of the billing software, and test the connection when logging in. If the connection is still abnormal, it is necessary to check whether the server address is "fpkj.chongqing.chinatax.gov.cn". Please refer to the treatment method in Article 13.

Sixteen, how to use tax Ukey to copy tax returns?

Enter the billing system, click Data Management/Data Processing/Summary Upload, or in the process navigation window on the homepage of the software, click the icon button of Summary Upload to enter the summary upload window, where taxpayers can summarize and upload the summary invoices to be reported as needed, click the button of Submit Summary to report and summarize the invoice data, and click the button of Update Monitoring to update the invoice monitoring data information to tax Ukey. (After the "update monitoring" is successful, the billing deadline will be postponed to the next month; Pay attention to check the billing deadline after the successful operation of backwriting monitoring. If you want to make a declaration in the current month, do the declaration after the "report summary" is successful, and then do the "write back monitoring"; If you don’t declare in the current month, you can directly "update monitoring" after the success of "reporting summary")

XVII. How to set the tax rate displayed by using tax Ukey to show "tax exemption"?

The operation of adding codes to commodities shall refer to Article 18; When assigning codes, check whether to use preferential policies. Preferential policies are tax-free, tax rate is 0, and export tax-free and other tax-free preferential policies are selected.

18. How to deal with the case of the value-added tax roll invoice issued by tax Ukey?

The printed roll invoice is numbered and printed separately. The machine number is the invoice number issued from the software, and the printed number is the invoice that comes with the jump number on the paper invoice itself, to judge whether the paper invoice has been issued in the software but is used. 1. If the paper invoice is issued in the software but has not been used, make up the invoice already issued in the software; 2. If the invoice that has not been opened in the software has been used, the paper invoice will be invalidated in the software. 3. The software has been issued and paper invoices have been used, but the invoice number of the machine number is not matched, and the current month’s invoice is invalid, and the cross-month negative invoice is red-offset. Note: Voided invoices Paper invoices must be in your own hands before they can be voided in the software.

1. For example, the machine number is 00666706, the invoice number is 00666705, and the software has been opened to 00666706. The paper invoice has just been printed to 0066705, so that 00666706 will be typed up in the invoiced query, and 00666705 will be invalid (if this problem has been discovered for several months, 00666705 will be red-stamped).

2. For example, the phone number is 00666708 and the invoice number is 0066712. 00666708 has been issued in the software, and the next one will be issued 00666709, but the paper invoice has been issued to 0066712, and the next one will be issued to 0066713. It is necessary to find the paper invoice of 00666709-00666712, and then void the unopened invoice. 00666708 It is not clear whether the correct invoice number printed by the user is correct or not. If the paper invoice of 00666708 is not correct, the invoice issued in the current month will be invalid, and the cross-month invoice will be red-offset.

3. The phone number is 00666602, and the invoice number is 00666702. The paper invoice in the software is 00666602, and the paper invoice in 00666702 is put in it. It is necessary to put the paper invoice in 00666602 to make up the invoice already issued in the software, and then when the software is opened to 0066702, the unopened invoice will be invalidated.

Tips:

Source: Chongqing Taxation

Original title: "The new invoice issuing tool" Tax UKEY "will meet you soon! Understand this knowledge first. "

With the strong rise of bio-economy, three generations of sequencing has brought a new answer to life science, "Huaxia Great Health Meeting Room"

Our reporter (chinatimes.net.cn) Wang Yu reports from Yu Na.

Recently, the first five-year plan of bio-economy in China-the "14 th Five-Year Plan for Bio-economy Development" was released, which indicates that bio-economy has become a brand-new economic form. The Plan points out that it is necessary to carry out cutting-edge biotechnology innovation, accelerate the development of Qualcomm quantitative gene sequencing technology, promote the new generation sequencing technology innovation marked by single molecule sequencing, and explicitly encourage the exploration of the third generation sequencing technology as an effective supplement to seek new solutions for complex gene mutation types beyond the scope of the second generation sequencing.

In fact, the third-generation sequencing is quite popular in recent years, which has attracted the attention of the whole industry, and many enterprises are actively deploying it. At the moment when the second-generation sequencing has become the Red Sea, everyone began to seek answers from the third-generation sequencing. So, how should this road of exploration go?

On the evening of June 8th, Dr. Gao Yang, chairman and general manager of Berry Gene, Wu Yingguang, general manager of PacBio Pacific Biotechnology, Sun Yuanyuan, general manager of Industrial Securities Great Health Research Center and chief researcher of pharmaceutical industry, and Li Gang, partner of Yikai Capital, visited the meeting room of Huaxia Great Health, and discussed frontier topics such as how to seize the beach in the era of bio-economy. The meeting room was presided over by Chen Yanpeng, assistant editor-in-chief of Huaxia Times and director of the Department of Big Health News.

The third generation sequencing has high growth.

Chen Yanpeng:

Third-generation sequencing is the focus of Berry’s gene layout. Berry’s gene is very forward-looking in this field. As early as 2019, it was announced that it had reached a long-term cooperation with PacBio Pacific Biotechnology, a well-known American third-generation sequencing company, on the development and clinical promotion of the third-generation sequencer, and the two sides jointly developed the third-generation sequencing platform. So what do you think, Gao Dong, is the thinking and planning of Berry gene in the layout of three generations of sequencing, and what is the force point of future clinical transformation?

Gao Yang:

We have laid out the field of three generations of gene sequencing, and in fact, we have gone through long-term research. What I want to explain is that the first generation, second generation and third generation sequencing technologies, unlike backwards compatibility in other fields, have their own technical characteristics and complement each other. Berry gene has been engaged in the diagnosis of rare diseases and genetic diseases for a long time. In this process, we found that some genetic diseases can not be effectively solved by first-generation and second-generation sequencing, let alone cost-effectiveness. Therefore, we are determined to bring more diagnostic methods to clinic with the most mature and stable third-generation sequencing technology in the world.

The layout of our third-generation sequencing is actually a state of scientific research first, hardware speeding up and products landing. Third-generation sequencing has developed for a long time in the field of scientific research, and there are a large number of scientific research documents, which have formed a technical demonstration in related fields. The hardware platform developed by Berry Gene and PacBio has entered the clinical trial stage of medical device registration. On the basis of hardware, we developed a genetic detection kit for thalassemia, and now it has entered the clinical trial stage.

We have observed that the acceptance of the third-generation sequencing products in China clinical market is very high. In the future, we will not only develop high-quality products, but also bring more cost-effective products to Chinese. We are confident to do a good job in screening and diagnosing a considerable number of patients with genetic diseases.

Chen Yanpeng:

PacBio Pacific Biotechnology is an advanced supplier of high-quality sequencing. Third-generation sequencing with high fidelity and long reading length has its unique advantages in technology, so in the era of bio-economy, there is a high-dimensional requirement for technological innovation. What do you think is the biggest problem that the third-generation sequencing technology will face?

Wu Yingguang:

The third-generation gene sequencing is very unique. It is very long and accurate. It can not only solve the problem of diagnosis, but also participate in solving the treatment problem (such as gene therapy) in the future.

In 2003, scientists published what was called the complete human genome sequence at that time, but there were about 8% blank regions without sequence data, which mainly included regions with highly repeated DNA fragments and regions with high GC content such as centromeres.

Until April, 2022, nearly 20 years later, Science published six papers in succession, and published the first complete gapless human genome sequence, which filled the missing "jigsaw puzzle" fragments in the past 20 years, mainly due to the great development of three-generation sequencing technology.

The third-generation sequencing technology has also greatly improved the ability of gene detection technology to solve clinical problems. Taking the diagnosis of rare diseases as an example, the conventional second-generation sequencing technology can only explain the pathogenesis of about 33% of rare diseases. The cooperation between PacBio and Children’s Hospital Mercy in the United States reveals that PacBio’s HiFi sequencing is expected to increase this percentage to 67% because of its excellent performance in SNV, Indel, SV and methylation.

Chen Yanpeng:

It is said that only by embracing the trend can we catch up with the trend. As a researcher in the secondary market, Mr. Sun, what do you think of the development trend and characteristics of the overall market of third-generation sequencing in the bio-economic era?

Sun Yuanyuan:

Our investment field is really concerned about the third-generation gene sequencing, and more capital will flood into this track in the future. From the perspective of the secondary market, I think the sequencing plate has strong growth and is a track with long slopes and thick snow. The growth of this track mainly comes from two points. First, it has a broad border, which determines that it has a long-term development space; Secondly, it belongs to intensive innovation, which determines that it has high growth and rich formats. In the future, a large number of sequencing projects will flood into the primary market, and then this track will get higher attention and financial support.

At present, human beings have extended the capability boundary of sequencing from the field of nucleic acid to the field of protein. From the perspective of technological innovation, as a new subdivision of sequencing, single-molecule sequencing has stronger technological innovation and faster technical iteration speed, and the downstream attention in this field is also very high. In the future, it will be promising in the growth track of sequencing.

Globally, the size of the third-generation sequencing market has reached 20 billion US dollars. Moreover, the penetration rate of the third-generation sequencer is only about 10% at present, and we think that the penetration rate will be further improved in the future. In the next few years, the global sequencing industry will maintain an average annual growth rate of 20%. The third-generation gene sequencing product of Berry Gene and PacBio Pacific Biotechnology is a good case of clinical transformation.

Chen Yanpeng:

At present, the third-generation gene sequencing is hot, and there will be more and more investment mergers and acquisitions on the third-generation sequencing in the market in the future. From a professional point of view, Mr. Li, as an investor, how do you think we should judge a high-quality third-generation sequencing enterprise target?

Li Gang:

I have been exposed to gene sequencing for quite a long time. I think that the first, second and third generation sequencing is not like a notebook chip. When a new generation comes out, it will completely iterate over the previous generation.

In fact, there are still many first-generation sequencing in clinical applications. For example, the first generation sequencing process is meticulous, there are many quality control links, it is not easy to be polluted, and the sequencing results are also very intuitive. If there is any doubt about the second-generation sequencing results, it will often be compared with the first-generation sequencing results. First-generation sequencing is still the gold standard in some scenarios. However, the first generation sequencing has a very big problem, that is, it takes a long time and costs a lot. Therefore, the second generation sequencing gradually rose. The second-generation gene sequencing technology has gradually entered the public’s field of vision. The second-generation gene sequencing technology is represented by Roche’s 454 technology, Illumina’s Solexa, Hiseq technology and ABI’s SOLiD technology. The second generation sequencing method firstly cuts DNA into small fragments randomly, and then connects adapter at both ends of these small fragments to make a DNA sequencing library.

The difference with the first-generation sequencer is that the second-generation sequencer adopts the synthetic sequencing method, that is, sequencing while synthesizing. While continuously extending primers by polymerase or ligase to obtain template sequences, the results of each round of reactions are collected and analyzed by fluorescence images, and finally the sequencing results of the whole sequence are obtained. The test speed is fast, the cost is low, and the high accuracy is maintained. Of course, the second-generation sequencer also has its shortcomings. Because of its technical route of cutting DNA into small fragments and amplifying it, the reading length of sequencing is short, and it will also bring various errors to sequencing during the amplification process.

The third generation sequencing technology refers to single molecule sequencing technology. When sequencing DNA, there is no need for PCR amplification, and each DNA molecule is sequenced separately. The third generation sequencing technology is also called de novo sequencing technology, that is, single molecule real-time DNA sequencing. The principle of the third generation sequencing technology is mainly divided into two technical camps:

The first camp is single molecule fluorescence sequencing, and the representative technologies are SMS technology of Helicos in the United States and SMRT technology of Pacific Bioscience in the United States.

The second camp is nanopore sequencing, and the representative company is Oxford nanopore company.

The research and development of third-generation sequencing needs a lot of financial support. I have made statistics. From 2019 to today, in more than three years, there have been about 24 cases of financing above designated size, with a total amount of about 12 billion yuan. Therefore, in terms of amount and quantity, the field of third-generation gene sequencing has grown very fast in the past three years.

Speed up the localization of sequencer

Chen Yanpeng:

We see that Berry Gene and PacBio are jointly developing three generations of desktop sequencers. At present, the topic of localization of sequencers is highly concerned. Gao Dong, how do you think to further speed up the localization of sequencers in the era of bio-economy?

Gao Yang:

Since localization is mentioned, I think the premise is to fully understand the China market.

In January of this year, we started to jointly develop three generations of desktop sequencer with PacBio. Why do you want to do this? Because the clinical market in China is multi-level, we should use hardware and appropriate kits to meet the multi-level needs. After investigation, we have come to a conclusion: the vast clinical market only needs sequencers to meet certain fixed applications. For example, the third-generation sequencer is mainly aimed at the variation of complex structure in clinic, which requires little sequencing quantity, but higher sequencing quality and intuitive data interpretation. In addition, the diagnostic ability of China hospitals for genetic diseases is still improving, and there is a great demand for desktop sequencers. When the third-generation desktop sequencer is successfully developed, it will be the first to be listed in China market in the form of localization.

To promote the localization process, this field is relatively new from the strategy of Berry Gene, and we are at the forefront in clinical transformation all over the world. We choose the best technical partners to locate and develop hardware platforms and kits suitable for China market. Only by meeting the clinical needs of China, the efforts to upgrade localization will be rewarded. Once the demand is met, the growth rate of the third-generation gene sequencing market at the clinical level will far exceed the scientific research level. I hope that in the future, in the field of third-generation sequencing, we can become a pioneer of technology, a promoter of the market, the backbone of hardware localization, and a bridge between clinic and patients.

Chen Yanpeng:

From the perspective of technology and application, Mr. Wu, what do you think will be the future direction of the third-generation sequencer, such as whether small and beautiful will become a big trend?

Wu Yingguang:

Clinical practice shows that the third generation sequencing can provide a higher health economic result. Take the third-generation thalassemia gene detection promoted by Berry Gene as an example. This is the first detection product based on the clinical application of third-generation sequencing technology in China. So far, our clinical tests show that the detection rate is almost 100%, and there are many mutations that cannot be detected in the first or second generation, all of which are detected by third-generation sequencing.

The second generation and the third generation are not a complete iterative or substitution process. I don’t think the technology of the third generation will stay in the small and beautiful stage, because it can really provide more answers and provide higher health and economic value, and it is bound to be applied in the mainstream.

Chen Yanpeng:

Because of its characteristics, third-generation sequencing is regarded as a new key to open the door. So in your opinion, what kind of "catfish effect" will the third-generation sequencing bring to the whole industry?

Sun Yuanyuan:

At present, the "catfish effect" can be seen. In the global sequencing market of nearly $20 billion, the downstream is developing faster than the upstream. According to the latest data, the downstream accounts for about 70% of the market. In the downstream market, the market growth rate of the clinical end is higher than that of the scientific research end, and the application scenarios of sequencing downstream are very diverse. In addition to being familiar with reproductive health, there are tumors, rare diseases and metabolic immunity in the clinical end. One of the characteristics of the third generation sequencing is that it has a good matching degree with many subdivision fields. In the future, the penetration of third-generation sequencing in the downstream segmentation field is worth looking forward to.

Chen Yanpeng:

In recent years, the market popularity of third-generation sequencing is getting higher and higher, and the industry also needs rapid, healthy and orderly development. What suggestions do you have for the policy level, Mr. Li?

Li Gang:

As far as regulatory policies are concerned, I think we should give these innovative enterprises with scientific and technological attributes a more relaxed environment. On the basis of strict standards for clinical trials of enterprises, enterprises should be given certain support in terms of technology, policy and even capital and listing.

Let the technology be applied to clinic faster.

Chen Yanpeng:

With the rapid development of third-generation sequencing and the continuous expansion of market scale, what roles do you think your enterprises play in this process?

Gao Yang:

In the field of third-generation gene sequencing, at present, it is a trend to transform from scientific research to clinical practice. Berry Gene is an enterprise that has been transformed and laid out in the clinical application of this gene sequencing field for a long time. We very much hope to seize and even lead the third generation of gene sequencing.

In this wave of clinical transformation, we hope to become the pioneer of third-generation sequencing technology, the promoter of the market and the backbone of hardware localization. We very much hope to develop a large number of products suitable for gene diagnosis and gene screening in China market by using the technology platform of third-generation gene sequencing. Berry Gene should play the role of a technical bridge between clinic and patients.

Wu Yingguang:

Since PacBio introduced high-fidelity sequencing technology in 2019, our business center has gradually shifted from traditional pure scientific research, especially in the field of animals and plants, to the field of human medical health. In my opinion, PacBio still has many very valuable things to do. First, at present, a considerable number of reference sets or various data and models of the human genome are basically based on ngs second-generation sequencing. With the establishment of a complete human reference genome, there are now many updates called pan-genomes, which we call disease-related databases, which will make our downstream clinical applications more accurate. Secondly, I think I can participate more in the clinical research of human genes and the health diagnosis industry, and deeply cooperate with Berry Gene, which can make the technology applied to clinic more quickly.

Sun Yuanyuan:

From the perspective of secondary market investment and research, our mission is to explore high-quality enterprises, grow together with excellent enterprises, and match the market valuation and enterprise value of enterprises.

At present, we also have a very strong team, our team now has 20 people, and the doctors in the team are also studying related sequencing majors in the United States. Third-generation sequencing is the long-term focus of our team. In the future, we also hope to serve as a bridge between enterprises and markets, so that more secondary investors can understand the potential and value of third-generation sequencing.

Li Gang:

As a bridge between capital and industrial enterprises, our investment bank has the largest medical and health team in China, with more than 70 people, all of whom focus on the medical and health field. Most people have professional backgrounds such as biology and medicine. Therefore, we hope that with the help of our familiarity with capital, industry and technology, we can effectively allocate capital and capital, and then these companies with promising technologies and development potential will develop and grow as soon as possible, providing more new medical technologies and treatments for patients in China and even around the world.

Sun Yuanyuan:

We pay more attention to the third generation sequencing, and the downstream application scenarios are assumed to be sorted. What do you think will be the next scenario?

Gao Yang:

Third-generation sequencing is first taken out to solve the screening and diagnosis of some relatively clear genetic diseases downstream. In the future clinical scene, we very much hope to achieve the screening of whole gene diseases and the diagnosis of unknown diseases.

Wu Yingguang:

In addition to the diagnosis discussed, I think the third-generation sequencing has a considerable prospect in the next treatment, especially in the field of gene therapy.

Chen Yanpeng:

Can you describe the future of the third generation sequencing technology in your mind in one sentence? What is your greatest expectation for it?

Gao Yang:

Third-generation gene sequencing has opened a brand-new door for our gene industry. I am very much looking forward to bringing some new ideas, new methods and new answers to practitioners in the whole industry.

Wu Yingguang:

Because the third generation sequencing is a typical single molecule real-time sequencing, its speed is actually very fast, and we hope to make further breakthroughs in this field.

Sun Yuanyuan:

I hope that the third generation sequencing can do what the second generation can’t do in the future and open up a pure incremental market.

Li Gang:

I expect the third generation sequencing technology and platform to be more accurate, faster and cheaper.

Editor in Charge: Guo Yilin Editor in Chief: Chen Yanpeng

Reporting/feedback

Surrogate twins lost their father, grandparents and foster mothers competed for custody, and the second trial was rejected.

The couple who failed to conceive after marriage are eager to have children, and try their best to find eggs and then "borrow the abdomen" to give birth to a pair of twins. However, something unexpected happened. A pair of children were only three years old, but the father of the child suddenly fell ill and died. For this reason, a lawsuit "war" broke out between in-laws and daughter-in-law for custody of the child.Mothers who have raised their children for many years are not related by blood, grandparents who are related by blood are too old to bear the heavy responsibility of raising, and the identity relationship between the two "mothers" who provided eggs and gave birth to children behind the case, and the inheritance of the father of the child …This lawsuit, which is entangled with family, blood and ethics, is doomed to be not simple.

On the morning of June 17, the Shanghai No.1 Intermediate People’s Court made a final judgment on this case, and rejected the grandparents’ claim to be guardians of their children and raise them.

After the verdict, the mother who raised the child for many years shed tears on the spot with her attorney.

Remarried couples "customize" surrogate twins

Jun Gao is the only son of Lao Gao and his wife. On April 28th, 2007, after two failed marriages, Jun Gao married lin li, who was also divorced. After marriage, lin li revealed to her husband that she was suffering from infertility and offered to raise children related to her husband. After discussion, the two decided to find someone to surrogate.

They found a surrogacy company online, bought other people’s eggs, provided sperm by Jun Gao, and entrusted another woman to give birth by in vitro fertilization combined with embryo transfer technology. Although it cost hundreds of thousands of yuan before and after, Jun Gao lin li finally got a pair of lovely dragon and phoenix twins Xiao Qing and Xiao Shi on February 13th, 2011.

The man died of illness, and his in-laws and daughters-in-law sued for "taking treasure"

In February 2014, Jun Gao died suddenly because of acute pancreatitis. The sudden change not only made the two children lose their father, but also caused irreconcilable contradictions between Jun Gao’s parents and wife because of their children.

On December 29th of the same year, Lao Gao and his wife brought lin li to court, and the two sides went to court for the custody and support of their children. Lao Gao and his wife claimed that their son Jun Gao was the biological father of the two children, but lin li was not related to the children by birth, so they asked him and his wife to obtain custody of the two children.In order to prove their parenting ability, Lao Gao and his wife also produced a promise from their daughter who lives in the United States, proving that her daughter is willing to help them raise two children.. Lilin firmly disagreed with the old man’s petition, saying that "I have been raising the two children, and they should be presumed to be the legitimate children of Jun Gao and me. If they can’t be identified as legitimate children, then they will live with me from the date of birth and form a de facto adoption relationship. " Lin li’s agent ad litem also argued that if the court could not identify Xiaoqing and Xiaoshi as legitimate children of Jun Gao and lin li or actually adopted children, the plaintiff Lao Gao and his wife’s claim to be guardians should also be rejected if they could not determine whether their biological mother died or lost their guardianship.

In the trial of the first instance, the court entrusted an authoritative organization to carry out DNA identification, and the conclusion was: Jun Gao’s parents, Xiao Qing and Xiao Shi were not excluded from the genetic relationship, but lin li could be excluded as the biological mother of Xiao Qing and Xiao Shi. On July 29th, 2015, the first instance ruled that Xiaoqing and Xiaoshi were under the custody of the plaintiff Lao Gao and his wife, while lin li entrusted Xiaoqing and Xiaoshi to the custody of two plaintiffs, on the grounds that the legal adoption relationship was not established due to the lack of statutory essential elements between lin li and Xiaoqing and Xiaoshi, and the surrogacy itself was not legal, and lin li and Xiaoqing and Xiaoshi did not constitute a fictitious blood relationship.

The second trial found that custody belongs to the foster mother.

After the judgment of the first instance, lin li refused to accept it and appealed to the Shanghai No.1 Middle School. On November 16th, 2015, the Shanghai No.1 Intermediate People’s Court held a public hearing to hear the appeal case. During the hearing, the two sides had a heated debate on the legal status of the children born by surrogacy, whether lin li and Xiaoqing and Xiaoshi established a fictitious blood relationship, and the custody of Xiaoqing and Xiaoshi.

Because Jun Gao ran the company before his death and left a lot of legacy after his death, lin li said in court: "If I get custody of the children, I will raise them by my own ability, and I agree that the court will freeze the property inherited by the two children until the children reach the age of 18." Lin li also said that if she obtained the custody of her two children, she would allow her parents-in-law to visit them. However, this statement was not accepted by Lao Gao and his wife, who always insisted on obtaining custody of their two children.

After hearing the case, Shanghai No.1 Intermediate People’s Court held that Xiaoqing and Xiaoshi were the children born by Jun Gao and other women through surrogacy after lin li and Jun Gao got married, and they belonged to the illegitimate children of one of the spouses after the marriage. After their birth, the two children lived with Jun Gao and lin li for nearly three years, and Jun Gao lived with lin li for two years after his death.Lin li, Xiao Qing and Xiao Shi have formed a stepparent-child relationship, and their rights and obligations are governed by the provisions of the Marriage Law on the relationship between parents and children.As grandparents, Lao Gao and his wife are in the custody order after lin li, so their claim for custody does not meet the conditions stipulated by law. At the same time, considering the principle of children’s best interests, it is more conducive to the healthy growth of children to obtain custody from lin li, so the appellee Lao Gao and his wife’s original claim was rejected.

The second trial found that custody belongs to the foster mother.

[Judge Wired] The legal relationship of surrogacy derivatives needs to be clarified

Hou Weiqing, the presiding judge and presiding judge of the collegiate bench in this case, said that the determination of paternity of the children born by surrogacy is complicated, which is related to the realization of the purpose of surrogacy, the interests of all parties, the protection of the rights and interests of the children born by surrogacy, and the public’s acceptance based on traditional ethical concepts and cultural background. At present, China’s laws lack relevant provisions on this. Theoretically, there are four theories: consanguinity theory, childbirth theory, contract theory (or artificial reproduction purpose theory) and children’s best interests theory. The court held that the "childbirth theory" conforms to the principle of "the parturient is the mother" in the traditional civil law, and is also the same as the standard of paternity in the other two artificial reproduction methods, and conforms to the traditional ethical principles and values of our country. In addition, the principle of "the parturient is the mother" is also consistent with the current position of prohibiting surrogacy in China. Therefore, it is concluded that the legal biological mother of the child born as a surrogate in this case should be recognized as a surrogate according to the principle of "the parturient is the mother"; The legal biological father is Jun Gao who is related by blood. Because there is no legal marriage relationship between Jun Gao and the surrogate, the children born are illegitimate children.

In this case, the foster relationship between stepparents and children was formed.

Hou Weiqing said that the scope of stepparents’ children should not be limited to children born in wedlock, but also include children born out of wedlock. However, when the Marriage Law distinguishes the stepparents-children relationship between lineal in-laws and fictitious blood relatives, it is based on the fact that there is upbringing education. As for whether the birth time of children is before or after the marriage, it is not the essential element to identify the stepparents-children relationship with dependency. In the past five years, lin li has completely regarded the two children as her own children, and has fulfilled the obligations of raising, protecting, educating and caring for the children as a mother. Therefore, it should be considered that the relationship between the two sides has been formed. Once the stepparents-children relationship of this fictitious consanguinity is formed, it will not be dissolved by the death of the parent of the husband and wife. Therefore, the death of Jun Gao cannot naturally terminate the existing stepparents-children relationship with lin li and his two children.

Surrogacy is illegal, but the interests of children are great.

Hou Weiqing also said that no matter how to deny and condemn illegal surrogacy, the children born by surrogacy should be innocent and their legitimate rights and interests should be protected by law. Therefore, children born in or out of wedlock, children born naturally or children born by artificial reproduction, including surrogacy, should be given equal protection. According to the principle of children’s best interests, considering the guardianship ability of both parties, children’s needs for living environment and emotion, and the influence of family structure integrity on children, it is more conducive to the healthy growth of children to have custody in lin li. Therefore, the custody of Xiaoqing and Xiaoshi should belong to lin li. (The characters in the text are all pseudonyms)